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These properties make DSIP a useful tool for studying neurochemical responses to stress and the downstream metabolic and endocrine effects of HPA axis activation

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[62] GPCR-independent signaling by heterotrimeric G-proteins [edit] Although it is a relatively immature area of research, it appears that heterotrimeric G-proteins may also take part in non-GPCR signaling

conversely, insulin can bind IGF1R with lower affinity than it has for the insulin receptor IGF1R and the insulin receptor can form heterodimers that bind both ligands IGF1 has actions distinct from those of growth hormone in carbohydrate, lipid and protein metabolism