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For example, intranasal insulin has been shown to enhance memory and reduce progression of white matter hyperintensity volume over 12 months, supporting its potential as a BBB-bypass therapeutic via olfactory and trigeminal pathways (Kellar et al., 2021)

Mechanisms of disease: advanced glycation end-products and their receptor in inflammation and diabetes complications

Ukr Khim Zh 22:603607 Pfeffer MA, Braunwald E, Moy LA, Basta L, Brown EJ Jr, Cuddy TE, Davis BR, Geltman EM, Goldman S, Flaker GC et al (1992) Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial

In addition to the psychotropic effects (due to the activation of the CNS CB1 receptor), THC by acting on CNS CB1: (1) Induces drowsiness and impairment of short term memory