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The unique electronic and redox properties of palladium--lipoic acid complex in Poly-MVA appear to be responsible for the exhibited effect

also found that in cisplatin-resistant ovarian cancer cells, KDM3A can activate SOX2 and inhibit p53 activity through demethylating p53, thereby downregulating the expression of apoptosis-related protein BCL-2 and p21, while inhibiting KDM3A can block the drug-resistant cells in G2/M phase (Fig

Furthermore, a high-fat or high-sugar diet resulted in greater severity of diabetes and glucose intolerance than in control animals (33)

Interestingly, the STAT3 transcription factor is the major inducer of the expression of this immunosuppressive armament, either directly or indirectly [9, 89, 93, 94]