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176 Some other noncoding RNAs and their potential downstream targets were identified and proposed in the heart in response to exercise training, such as miR-1 and miR-214 (targeting NCX and SERCA2a), 177 miR-27a/b and miR-143 (targeting angiotensin-converting enzyme-Angiotensin II genes), 178 miR-208a/b (targeting Med13, Pur, Sox6, HP1, and SP3), and miR-21, miR-144, miR-145, miR-124 (targeting PI3K/AKT signaling)

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IGF-1 forms the central core elements of astrocyte functions, such as the regulation of glucose uptake, glutamate transport, and protection against oxidative stress in the brain [44, 131, 132]

10.3389/fimmu.2023.1051606 111 XiaY.YangR.WangH.HouY.LiY.ZhuJ.et al (2022a)