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Following administration in rodent models: Rapid systemic distribution following intranasal or intraperitoneal administration Peak biological effects observed within 15-30 minutes of intranasal delivery Penetration across the blood-brain barrier to reach central nervous system targets Preferential uptake in well-vascularized organs including liver, kidney, and heart Intranasal administration studies revealed that despite rapid plasma clearance, central nervous system effects persisted for hours, suggesting either tissue retention or sustained signaling cascade activation independent of plasma concentrations

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The median age was 45 years (IQR, 32-59)