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Currently, there is no scientific basis for performing genetic testing in AMS patients except in research protocols.18,58,59 CONCLUSION AMS demonstrably increases the risk of developing melanoma, a malignant neoplasm for which incidence have increased significantly in recent decades and for which early diagnosis is of great importance in the prognosis of the disease.4,59 The identification of patients with AMS, the main clinical risk factor, allows them to be included in short and long term monitoring programs, aimed at early detection of suspicious lesions and the consequent reduction in mortality associated with advanced melanoma.42 In addition, a prevention program could contribute to increased awareness and changes in risk behavior, minimizing the environmental risk not only for patients but also for their families

Although the pathogenesis of nevi remains unknown, it has been suggested that the lesions are benign neoplasms

The reason for the long wait is unclear, but it may be telling that the company that initially developed PT-141 (King Pharmaceuticals) was acquired in 2010 by Pfizer, which famously manufactures Viagra and had a vested interest in keeping PT-141 off the shelves until after Viagras patent expired in 2020