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Description

TRPML1-mediated Ca 2+ release drives phagosome maturation and phagosome-lysosome fusion, processes that engulf and degrade pathogens in macrophages

The elevated expression of Pfkfb3 in astrocytes facilitates the continuous production of fructose-2,6-bisphosphate, an allosteric activator of phosphofructokinase (PFK), which accelerates glycolysis (Blanger et al., 2011)