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10.1161/CIRCULATIONAHA.111.060368 152 Sharifi-RadMKumarN

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology

Structural and pharmacological studies demonstrate that Cagrilintide binds these receptor complexes with high affinity in a manner that resembles endogenous amylin while incorporating modifications that increase peptide stability and prolong receptor engagement [2]