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Hydrolytic cleavage leads to unstable constituents obtaining, thus, polysaccharide fragmentation (37)

Although many of the studies in humans reported conflicting results, there was consistent evidence that aspartame increased serum insulin levels in lambs and in several studies in rodents, indicating alterations in insulin sensitivity, including changes to lipid metabolism

The PE N-methyltransferase (PEMT) pathway uses SAMe to methylate PE yielding PC and being affected by both SAMe increase and depletion which ultimately can lead to dysregulation of VLDL secretion and result in liver disease, atherosclerosis and obesity [38,39,40]

They're great in a diet as an amazing immune system and detoxifying stimulant