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Activation of the zymogen of hepatocyte growth factor activator by thrombin

The increase in NO, a potent vasodilator, likely contributed to the observed reduction in blood pressure 21

In addition to the disease process being associated with a breach in the intestinal barrier functions, patients with hematologic and oncologic diseases are particularly at high risks for the development of increased intestinal permeability, due to the frequent use of broad-spectrum antibiotics and chemoradiation

What doesn't work as a primary treatment: tennis ball rolling (comfort, not therapy), heel cups alone without mechanical correction, and long-term NSAID use