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TFAM is almost exclusively present in a DNA-bound form (Takamatsu et al., 2002), and degradation of TFAM proteins by mitochondrial matrix proteases directly affects mtDNA copy number (Matsushima et al., 2010)

Chen R, Zhao L-D, Liu H, Li H-H, Ren C, Zhang P, Guo K-T, Zhang H-X, Geng D-Q, Zhang C-Y (2017) Fluoride Induces Neuroinflammation and Alters Wnt Signaling Pathway in BV2 Microglial Cells

We also note that we referenced the requirement that providers follow reasonable cost principles under section 1861(v)(1)(A) of the Act when completing Medicare cost reports and reiterate that section 1861(v)(1)(A) of the Act requires reporting of data elements beyond just cost, including non-cost items and items used to determine the cost of services

In addition, we observed PKC/ co-immunoisolated with SORLA in the IP complex (Fig