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273 In addition, in a rat model of inflammatory OA induced by monoiodoacetic acid (MIA), researchers have shown that the activation of GLP-1R triggers the PKA/CREB signaling pathway, leading to a reduction in cartilage inflammation

Zingales V, Distefano A, Raffaele M, Zanghi A, Barbagallo I, Vanella L (2017) Metformin: a bridge between diabetes and prostate cancer

These events include nausea, hypotension, psychiatric events, diarrhea, and dyskinesia