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Note: long-term use of drugs that affect stomach acid production such as H2 blockers and proton pump inhibitors can worsen B12 deficiency

Such plans could be in the form of optimising dosages and prescriptions that would achieve the most benefit while causing the least harm or side effects to the individual

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(Wu et al., 2019) demonstrated in human umbilical vein ECs and arteries of HHcy mice that Hcy triggers the expression of ER oxidoreductin-1 (Ero1), leading to ER stress and subsequent inflammation