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ALK5 knockdown and its downstream pathway protected LUHMES cells from aSyn-induced toxicity To verify that the knockdown of ALK5 protected against aSyn-induced toxicity, we first validated whether the siPOOL siRNA against ALK5 could effectively and specifically reduce ALK5 mRNA expression

In particular, we hereby propose the putative functionally relevant conformational change of the C terminus after the transfer of reducing equivalents from NADPH to the redox sites of the enzyme.

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