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Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic

The most extensively documented involves upregulation of vascular endothelial growth factor (VEGF) and its receptor VEGFR2, promoting angiogenesis, the formation of new blood vessels, in injured tissue

178-180 However, a meta-analysis of eight clinical trials found low-dose naltrexone slightly reduced pain and symptom severity in patients with fibromyalgia but was not significantly more effective than placebo