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Omiya S, Hikoso S, Imanishi Y, et al

Severe adverse event (AE) beyond grade 3 was 12.9%, AE of Grade 5 (hemoptysis, pneumonitis, variceal bleeding, duodenal ulcer perforation, autoimmune hepatitis) was 3.1%

278 More importantly, p53 can adjust gluconeogenesis, glycolysis, and glucose uptake to affect glucose metabolism in peripheral tissues

According to NICE guidance and standard UK clinical practice, patients with confirmed B12 deficiency and neurological symptoms typically require initial treatment with hydroxocobalamin injections