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Many of these placebo-controlled studies have demonstrated that folic acid supplementation improved symptoms in severely depressed patients, elderly depressed and demented patients, and those with major acute depression or schizophrenia, particularly in individuals with RBC folate levels below 453 nmol/L (46)

However, folic acid cannot fix the damage to the nervous system caused by low B12, which can lead to permanent nerve damage if the B12 deficiency isn't found and treated