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Additionally, it is essential to embryonic development because it involves cell division, DNA synthesis, cellular differentiation, and the maintenance of cytoplasmic integrity

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To date, eight different variants, including three frameshift mutations (37.5%), two missense mutations (25.0%), one nonsense mutation (12.5%), one copy number mutation (12.5%), and one six-base in-frame deletion (12.5%), have been reported in China in 10 patients from nine unrelated families (Table 1)