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Keywords Salicylate Toxicology Source: aspirin or your local willow tree Mechanism of Action: Salicylates cause an uncoupling of oxidative phosphorylation Catabolism occurs secondary to the inhibition of ATP-dependent reactions with the following results: increased oxygen consumption,increased carbon dioxide production, accelerated activity of the glycolytic and lipolytic pathways, depletion of hepatic glycogen,hyperpyrexia Dosages: The usual daily dosage range for aspirin is two regular strength aspirin tablets (325 mg x 2 = 650 mg) every 4 hours (or 12 tablets/day)

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doi: 10.3389/fphar.2026.1776489 Received 27 December 2025 Revised 17 April 2026 Accepted 22 April 2026 Published 14 May 2026 Volume 17 - 2026 Edited by Adrian Oo, National University of Singapore, Singapore Reviewed by Abayeneh Girma, Mekdela Amba University, Ethiopia Robert Tancer, NJMS, Rutgers Newark, United States Updates Copyright 2026 Sachivkina, Saha, Gurina, Kuznetsova, Zhabo, Avdonina and Pilshchikova