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8.3 Summary of meta-analyses and reviews In an extensive review focused on role of NAC in pediatric respiratory conditions Beneditti et al

Almost all inflammatory diseases exhibit evidence of enhanced oxidative stress (18)

Consistently, the treatment of HIV Tg rats with NAC resulted in the failure of cART to mediate microglial activation, and this was also accompanied by the restoration of impaired lysosomal and autophagy processes

In the first study investigating candidate genes associated with the disease, human leukocyte antigen (HLA) class I and II genes were identified as major genetic risk factors