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To reconcile the opposite effects of V-ATPase dysfunction on autophagy flux in nutrient-rich versus starvation medium, we reasoned that dysfunction of the V-ATPase may have dual roles in autophagy regulation: On the one hand, it hampers vacuolar hydrolytic activities (but vacuolar proteases such as Pep4 are still partially active)

An older adult with poor appetite, anemia, and low B12 will often regain weight once the deficiency is corrected

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Chemical & Physical Characteristics Compound Class: Small-molecule NNMT inhibitor (quinolinium derivative) Molecular Formula: CHN Appearance: Off-white to pale yellow powder, encapsulated for oral research administration Solubility: Water-soluble