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The goal of syringe barrel siliconization is to allow the plunger to glide smoothly within the barrel, whereas the silicon coating of the needle prevents it sticking to the skin

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Nat Rev Drug Discov 1:769783

Their results also suggested that NK1 and NK3 receptors may induce glandular effects by different mechanisms NK3 receptors are likely inducing activation of parasympathetic nerves, while NK1 may have direct effect on the glands [80]