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Additionally, postoperative pain can lead to gut microbiota dysbiosis, as the stress and inflammatory responses triggered by pain may disrupt the delicate balance of gut microbiota (Pusceddu and Gareau, 2018)

When fish perceive a stressor, the hypothalamus secretes corticotropin-releasing hormone (CRH), which stimulates the pituitary gland to release adrenocorticotropic hormone (ACTH)