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Glutathione S -transferase P1 expression in cancer patients may also be influenced by the presence of allelic variants GSTP1 Ile 105 Val (rs1695) and GSTP1 Ala 114 Val (rs1138272), with homozygote rare allele frequencies of approximately 12% and 2% in the Caucasian population, respectively (Zimniak et al, 1994

Indeed, a significantly lower glutathione-S-transferase (GST) enzyme activity and significantly high MDA levels have been shown in the cumulus cells of poor responders compared to high responders (220)

These observations from early signaling involving the interplay of flavonoids and Nod factor production are a clear example of how a potential stress, flavonoids, induce a bacterial signal, Nod factor, that have become a key component for symbiotic interaction