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Preclinical data in rodent models showed approximately 37% greater hepatic fat reduction versus tirzepatide-equivalent dosing, a finding cited in multiple human trial design rationales as justification for the Retatrutide vs Tirzepatide superiority hypothesis in hepatic metabolic disease contexts

The NRF2 target biliverdin reductase metabolizes biliverdin to bilirubin [30]

Designing probes that can produce different reaction products or bind specifically to GSH rather than Cys and Hcy can help improve specificity

The total injection volume of drug solution was tuned as 500 L , and the solution was administered at two different injection rates of 25 L/min and 100 L/min