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In the context of an animal model of TBI, it is possible to directly administer therapeutic agents to the cerebrospinal fluid (CSF) via an intraventricular pathway

Curr Pharm Des 27:490504

By focusing on solvent exposure regions, structural optimization of compound molecules can enhance drug affinity and selectivity, improve drug solubility and bioavailability, reduce drug side effects, and overcome drug resistance

Although the KV11 peptide did not have a considerable effect on breast cancer growth and proliferation in mice transplanted tumor models with an intense combined immune deficiency, it prevented the growth of the tumor by suppressing angiogenesis