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Furthermore, silibinin may modulate immunity by suppressing HIF-1 in colon cancer (CT26) and ovarian clear-cell carcinoma (HAC-2, OVISE, and RMG-1) cells, influencing the tumor immune landscape [878, 898]

Age is another key factor, with the likelihood of vasodilation, AAA formation and rupture increasing over time and rupture leading to death in up to 90% of cases (177)