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However, as genotyping is not currently routinely available and serum vitamin B 12 measurement is cheap, our results reinforce the causal association of metformin treatment with vitamin B 12 deficiency and guideline recommendations for routine screening for vitamin B 12 deficiency in people treated with metformin

Mistake 3: reducing the dose when side effects occur instead of holding steady When nausea or other GI symptoms appear after a dose increase, some researchers immediately drop back to the previous dose

StatPearls [Internet] 94

The endoplasmic reticulum (ER) is a complex dynamic structure possessing many functions in the cell, the most important ones include calcium storage, lipid metabolism, and protein synthesis (Cao et al