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Initial velocities, v 1 , at different substrate concentrations, [S] were fitted to the Michaelis-Menten equation shown in Eq

ABC transporters play a crucial part in cancer drug resistance, as they can increase the cellular efflux of anticancer drugs 65

This is in agreement with previous observations that electron tunneling between redox centers separated by distances below 14 occur at rates fast enough not to be a limiting factor for substrate turnover 15