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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]

This pathway relies on -catenin, which is activated by binding extracellular Wnt ligands to membrane receptors through autocrine and paracrine processes, inhibiting the degradation of -catenin so that it can be stably accumulated in the cytoplasm and transferred to the nuclear compartment, where it can work together with T cell factor/lymphoenhancer binding factor to stimulate the transcription of target genes

Interestingly, emerging research indicates that cancer stem cells (CSCs) can also be targeted by bioactive compounds that can protect against cancer development (Opara et al