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Rockhill K

A complete health history is required before any protocol is initiated

Once telomeres become critically short, the cell enters senescence as a protective measure to avoid chromosomal instability and potential malignant transformation.12 Telomeres shorten with each cell division due to the end-replication problem in DNA synthesis

Finally, MALDI-TOF mass spectrometry (MS) confirmed efficient cleavage of the 33-mer by Clc at three QPQL/P sites at pH 3, generating 9-, 7- and 3-mer fragments (Fig