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Tappenden KA, Quatrara B, Parkhurst ML et al (2013) Critical role of nutrition in improving quality of care: an interdisciplinary call to action to address adult hospital malnutrition

Period proteins PER13 and Cryptochrome ones CRY12 form complexes, and translocate to the nucleus to inhibit CLOCK-BMAL1 activity, thus closing the negative feedback loop

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Given the promising results in animal studies, clinical studies are required to evaluate the effect of sulforaphane on neurological outcomes in humans