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Primary in vivo endpoints targeted effects of ~ 2030% (SD ~ 1015%), for which n 8 per group gives ~ 80% power at = 0.05

van NorrenKKeglerDArgilesJMLuikingYGorselinkMLavianoAet al

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"A double-blind, randomized phase II study to evaluate the safety and efficacy of acetyl-L-carnitine in the prevention of sagopilone-induced peripheral neuropathy." Oncologist 18(11): 1190-1191