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Chen F, Zhu S, Kang R, Tang D, Liu J

However, significant controversy exists regarding the relative contributions of these parallel pathways in different cellular contexts

Simultaneously, Akt activation suppresses the ubiquitin proteasome system through inhibition of FoxO-mediated transcription of E3 ubiquitin ligases (MAFbx/Atrogin-1, MuRF1), which are responsible for protein degradation