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This may explain why it reduces discomfort in wound models in addition to accelerating repair

KD of HACE1 , which encodes an E3 ubiquitin-ligase involved in the UPS, was shown to exacerbate LPS-induced inflammation in BV2 microglia [237]

(2) the upregulation of drug efflux pumps (e.g., MRP1-2), which can actively pump ATO and its metabolites out of the cell, reducing intracellular accumulation