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34 In a similarly sized double-blind, placebo-controlled study of intravenous ketamine (0.2 mg/kg) for treatment of migraine in the emergency department setting, however, ketamine was not superior to placebo for acute pain relief and caused adverse effects of generalized discomfort at 30 minutes and fatigue at 60 minutes, although no serious adverse events occurred

Three decades of promising animal data without human validation is unusual and should temper enthusiasm

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