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High doses of glutathione, particularly through injections, may lead to reduced melanin levels, which can result in white or grey hair as a side effect of skin whitening treatments

Bibcode:2014FrMaS...1...34W

It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate