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Additional research considerations include characterizing whether the enhanced membrane permeability of the acetylated form alters tissue distribution in in vivo models, whether the modified charge distribution affects receptor or chromatin binding dynamics, and whether the extended half-life requires adjusted concentration protocols in cell culture systems

Abdel-Kader R, Hauptmann S, Keil U, Scherping I, Leuner K, Eckert A, Muller WE

Journal of Medicinal Chemistry Deep Dive Why This Peptide

In our study, the motor cortex with TDP-43 pathology displayed increased GSSG/GSH ratio indicating ongoing oxidative stress