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Glycyl-L-histidyl-L-lysine (GHK) is a peptide found naturally in plasma, saliva, and urine, and its concentration tends to diminish with increasing age (Dou et al., 2020)

Thus, obesity induced by an HFD autonomously accelerates the development of associated pathological changes in OA progression and intensifies the advancement of pre-existing OA

[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Patone M., Mei X.W., Handunnetthi L., Dixon S., Zaccardi F., Shankar-Hari M., Watkinson P., Khunti K., Harnden A., Coupland C.A.C., et al

Or you may have unfortunately developed something autoimmune due to a significant ramp-up of immune reactivity combined with a genetic predisposition