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When to Update from D64.9: Once iron-deficiency, B12-deficiency, or other types are confirmed, switch to: D50.9 for iron-deficiency anemia D51.0 for vitamin B12 deficiency D63.1 for anemia in chronic diseases Use D64.9 only as a placeholder never as a long-term code in a patients chart

Laughlin GA, Barrett-Connor E, Criqui MH, Kritz-Silverstein D (2004) The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the rancho bernardo study

Cell Death Dis 2:e244

Utilizing estimands helps to address these uncertainties and improve transparency in clinical trial reporting by better matching the treatment-effect estimates to the scientific and/or clinical questions of interest