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10.1016/j.intimp.2018.04.008 98 KapoorM.MoriwakiM.TimmD.SatomotoK.MinegawaK

Trpv4 regulates Nlrp3 inflammasome via SIRT1/PGC-1alpha pathway in a cuprizone-induced mouse model of demyelination

A 30-year-old likely has far fewer senescent cells than a 60-year-old, which means: Younger individuals may notice less from FOXO4-DRI simply because there are fewer target cells to clear Older individuals or those with conditions associated with accelerated senescence (chronic inflammation, metabolic syndrome, prior chemotherapy) may have more to gain and more pronounced initial side effects from a larger clearance event Overall Health and Immune Function The immune system must clear apoptotic cells after FOXO4-DRI triggers their death