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From a therapeutic standpoint, their main opportunity may be combination design: pairing ferroptosis induction with interventions that remodel mitochondrial electron flow or substrate availability, thereby constraining the capacity to regenerate CoQ 10 H 2

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2 Nonpharmacologic Treatment Nonpharmacologic treatment options include physical therapy, surgery, transcutaneous electrical nerve stimulation (TENS), and acupuncture

MMAI models could potentially identify patients with high predicted MDSC signatures who could benefit from MDSC targeted therapies