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Fission is mediated by the recruitment of Drp1 from the cytosol to the outer membrane, forming a contractile ring, which cleaves the mitochondrion (Los n et al., 2013)

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In contrast, in non-glucose starved cells, with the presence of 10 mM glucose in all perfusion buffers, no NADP oxidation was observed, even with continuous perfusion of buffer containing 20 M H 2 O 2

Given the beneficial effects of several precursors and inhibitors summarized above, these strategies may be promising for finding a therapeutic strategy for AD, either as lead molecules or in combination approaches with other classes of molecules or drugs, with several studies having been launched at the clinical level