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If the 24-week trial could not demonstrate significant weight loss, there is no reason to believe that longer use would produce dramatically different results

8 Overall survival improvements were also noted in the CASTOR and POLLUX studies with the addition of daratumamab

Subcutaneous injection is the most common research-context format today, but no published human pharmacokinetic study has formally characterized subcutaneous AOD-9604 (this gap was specifically called out in FDA's December 2024 review)

Further studies are required to determine the relative contribution of this novel lipase to basal lipolysis and to in vivo lipase activity in adipose tissue