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There is much evidence for mitochondrial dysfunction and consequent oxidative stress and inflammation in sepsis

Chromatographic System and Conditions

The proposed expert opinion planned to provide a practical and implementable guidance document addressing DPN in terms of: a) definition, pathophysiology and risk factors, b) clinical manifestations and diagnosis (current challenges, a proposed screening and diagnostic algorithm), c) screening for early diagnosis and symptom progression, and d) management of disease in terms of the optimal diabetes treatment (intensive glycemic control, lifestyle modification and multifactorial risk intervention), the pathogenetically oriented pharmacotherapy (with special emphasis on alpha lipoic acid), and the symptomatic pain relief (in painful DPN)