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doi: 10.1111/bph.13702 [DOI] [PMC free article] [PubMed] [Google Scholar] 531

doi: 10.1016/s0014-4886(02)00060-2

Copper Chelation and Delivery At the most fundamental level, GHK functions as a copper chelator and delivery system - the tripeptide binds Cu with exceptionally high affinity (binding constant approximately 10 M, among the highest known for biological copper chelators), forming a square planar coordination complex where the copper ion is coordinated by the nitrogen atoms of the terminal amino group, the two peptide bonds, and the imidazole nitrogen of histidine

CrossRef Myosteatosis and Type 2 Diabetes Mellitus Lucian Batista de Oliveira, Vanessa de Oliveira e Silva, talo Caio Lopes Juc, Joo Victor Gonalves dos Santos Torres, Maria Roseneide dos Santos Torres, Fabio Moura, Francisco Bandeira Acta Medica (Hradec Kralove, Czech Republic).2025