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The components of glutamine metabolism, including metabolic enzymes, metabolites, and metabolite transporters, demonstrate high sensitivity and specificity in diagnosis, relapse monitoring, and stage prediction

Furthermore, the ethical constraints of testing novel therapies in pregnant populations, given potential fetal harm, limit the available translational pathways, exacerbating the gap between preclinical promise and clinical application [68]

Patients may present with pharmacogenomic information from other healthcare systems, clinical trials or, increasingly, from direct-to-consumer genomic testing (caution should be exercised when interpreting results from non-validated genomic tests)