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Ocrelizumab, which is sometimes called an Ocrevus injection, is an intravenous injection used to treat various types of multiple sclerosis, such as clinically isolated syndrome, active secondary progressive disease, relapsing-remitting MS (RRMS), and primary progressive multiple sclerosis (PPMS)

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(2014, Nature Medicine) established NNMT as a major regulator of metabolic rate in white adipose tissue, showing that NNMT knockdown in mice produced a lean phenotype with elevated energy expenditure providing the foundational rationale for NNMT inhibition as a metabolic research target

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