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Probiotic products, such as Limosilactobacillus reuteri, enhance the expression of heat shock proteins(heat shock protein 70 (HSP70), HSP25), promote tight junction protein synthesis, and alleviate inflammation-induced intestinal barrier damage [385]

10.1038/mp.2015.151 22 GebelS.MllerT

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The necessity for appropriate comparators and the patient-specific nuances of TE interventions pose challenges in conducting traditional randomized controlled trials (RCTs) or extrapolating findings across patients