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DAutraux B, Toledano MB (2007) ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

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Hence, it is also possible to assess the occurrence of an in vivo DILI episode by monitoring liver biomarkers in other biological fluids such as serum or urine, obtained by non-invasive or minimally invasive procedures, avoiding the need for liver biopsies for diagnostic purposes

Gain-of-function mutations disrupt this equilibrium by enhancing cation leakage and facilitating the dehydration of RBCs, resulting in hereditary xerocytosis